This focus is based on the following considerations. The principal focus of the lab is the role of the gut microbiota in defining healthy growth of infants and children and in the pathogenesis of malnutrition. We are interested in the following basic questions: What mechanisms govern assembly of gut microbial strains into a community after birth? Does the gut microbial community undergo an identifiable program of functional maturation in healthy infants and children that is shared across biologically unrelated individuals living in different parts of the world? What are the consequences of disruption of normal gut community development on the health status of growing infants and children (i.e., their physiologic, metabolic, immunologic and neurodevelopmental phenotypes)? The vast majority of these microbes live in our gut where they specify traits we have not had to evolve on our own. We are no exception: the total number of microbial genes in our body’s microbial communities is several orders of magnitude greater than the number of genes in our human genome. Mutually beneficial relationships between microbes and animals are a key feature of life on our microbe-dominated planet. Paul Janssen Award for Biomedical Research, 2023 Clinical Medicine Award from the National Academy of Medicine, 2022. David and Beatrix Hamburg Award for Advances in Biomedical Research, 2022.BBVA Frontiers of Knowledge Award in Biology and Biomedicine, 2018.Sanofi-Institut Pasteur International Award for Biomedical Research, 2017.Jacobaeus Prize, Novo Nordisk Foundation, 2017.King Faisal International Prize in Medicine, 2015.Member, American Philosophical Society, 2014.Waksman Award in Microbiology, National Academy of Sciences, 2013 Association of American Medical Colleges Award for Distinguished Research in the Biomedical Sciences, 2012.Member, Institute of Medicine of the National Academies, 2008.Member, American Academy of Arts and Sciences, 2004.Member, National Academy of Sciences, 2001.Member, Association of American Physicians,1989.Director, Edison Family Center for Genome Sciences and Systems Biology.Physician Scientist Training Program Directory.Faculty Development Faculty Development.Barnes-Jewish Hospital Molecular Diagnostics Laboratory.Clinical Laboratory Sections and Medical Directorships.Cytogenetics and Molecular Pathology Laboratory.
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